Neber rearrangement

Source: Wikipedia, the free encyclopedia.

The Neber rearrangement is an

ketoxime is converted into an alpha-aminoketone via a rearrangement reaction.[1][2][3]

Neber rearrangement

The oxime is first converted to an O-sulfonate, for example a

nucleophilic displacement to an azirine
and added water subsequently hydrolyses it to the aminoketone.

The Beckmann rearrangement is a side reaction.[4]

References

  1. OCLC 642506595
  2. doi:10.1002/jlac.19264490108
    .
  3. doi:10.1021/cr60228a001
    .
  4. ISBN 978-0-08-097743-0
    , retrieved 2022-10-10


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