Nef (protein)
Negative factor, (F-Protein) or Nef | |||||||||
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OPM superfamily | 269 | ||||||||
OPM protein | 2nef | ||||||||
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Nef (Negative Regulatory Factor) is a small 27-35 kDa myristoylated
Function
The expression of Nef early in the viral life cycle ensures
By down regulating cell surface expression of
To further evade the host immune response, Nef down-regulates the cell surface and total expression of the negative immune modulator
Cytoskeletal remodeling is thought to reduce TCR signaling during early infection and is also modulated to some degree by Nef.
Clinical significance
The Sydney blood bank cohort (SBBC) were a group of eight patients who were asymptomatic many years after initial infection by transfusion from an infected blood donor. Later analyses showed that the virus strain was a Nef-deleted variant.[7]
Vaccine
A Nef-deleted virus vaccine has not been tried in humans although it was successfully tested in Rhesus macaques.[8][9]
See also
- HIV structure and genome
References
- PMID 15817946. Archived from the original(PDF) on 2017-08-10. Retrieved 2008-08-07.
- ^ Marcey D, Somple M, Silva N (2007-01-01). "HIV-1 Nef Protein". The Online Macromolecular Museum Exhibits. California Lutheran University. Retrieved 2008-08-06.
- PMID 23227982.
- PMID 20594957.
- PMID 11463741.
- PMID 23372701.
- PMID 10352163.
- PMID 1470917.
- PMID 15928037.
Further reading
- Piguet V, Trono D (1999). "The Nef protein of primate lentiviruses". Rev. Med. Virol. 9 (2): 111–20. S2CID 25108310.
- Janardhan A, Swigut T, Hill B, et al. (January 2004). "HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis". PLOS Biol. 2 (1): e6. PMID 14737186.
External links
- Michael Smith. "HIV protein hides infected cells from immune system". MedPageToday.com. Retrieved 2008-09-26.