Nef synthesis

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Not to be confused with Nef isocyanide reaction or Nef reaction.
Nef synthesis
Named after John Ulric Nef
Reaction type Coupling reaction
Identifiers
RSC ontology ID RXNO:0000506

In organic chemistry, Nef synthesis is the addition of sodium acetylides to aldehydes and ketones to yield propargyl alcohols.[1][2][3][4][5][6] It is named for John Ulric Nef, who discovered the reaction in 1899.

This process is often erroneously referred to as the Nef reaction,[4][7][8][9] which is an unrelated chemical transformation discovered by the same chemist.

See also

  • Alkynation

References

  1. doi:10.1002/jlac.18993080303
    .
  2. ^ Johnson, A. W. (1946). The Chemistry of the Acetylenic Compounds (1st ed.). London: Arnold. p. 11. Retrieved 25 February 2016.
  3. doi:10.1021/ja01194a018
    .
  4. ^
    doi:10.1021/ja01174a048
    .
  5. ^ Raphael, Ralph Alexander (1955). Acetylenic Compounds in Organic Synthesis (1st ed.). London: Butterworths. p. 10. Retrieved 25 February 2016.
  6. doi:10.15227/orgsyn.020.0040
    .
  7. doi:10.1002/ange.19720840843
    .
  8. ^ Wolfrom, Melville L. (1960). "John Ulric Nef: 1862—1915". Biographical Memoirs (PDF) (1st ed.). Washington, DC: National Academy of Sciences. p. 218. Retrieved 24 February 2016.
  9. ISBN 9780471720911
    .


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