Neil Brockdorff

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Neil Brockdorff

X inactivation[2]
InstitutionsUniversity of Oxford
ThesisThe effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985)
Websitewww.bioch.ox.ac.uk/research/brockdorff

Neil Alexander Steven Brockdorff FRS FMedSci FRSB[5] (born 1958) is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.[6][7] Brockdorff's research investigates gene and genome regulation in mammalian development.[8] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.[8]

Education

Brockdorff was educated at Hampstead School, the University of Sussex (BSc)[3] and the University of Glasgow (PhD).[4]

Career and research

X inactivation is an important model for understanding how

epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.[8][9] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.[10][11] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.[8][12][13][14]

Awards and honours

Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).

References

  1. ^ "EMBO MEMBER: Neil Brockdorff". people.embo.org. Retrieved 12 June 2018.
  2. PMID 28947664
    .
  3. ^ a b c Anon (2019). "Brockdorff, Prof. Neil". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  4. ^
    EThOS uk.bl.ethos.379306
    .
  5. ^ "Professor Neil Brockdorff - The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 12 June 2018.
  6. ^ "Brockdorff Lab". sites.google.com. Retrieved 12 June 2018.
  7. ^ "Prof Neil Brockdorff Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Retrieved 12 June 2018.
  8. ^ a b c d Anon (2018). "Professor Neil Brockdorff FRS". royalsociety.org. London: Royal Society. Archived from the original on 6 June 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  9. PMID 15525528. Free access icon
  10. S2CID 4329368
    .
  11. S2CID 19889657
    .
  12. PMID 28947653. Open access icon
  13. ^ Neil Brockdorff publications from Europe PubMed Central
  14. S2CID 2317691. Closed access icon

 This article incorporates text available under the CC BY 4.0 license.

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