Neoendorphin

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Neoendorphins are a group of

β-neoendorphin. The α-neoendorphin is present in greater amounts in the brain than β-neoendorphin. Both are products of the dynorphin gene, which also expresses dynorphin A, dynorphin A-(1-8), and dynorphin B.[2] These opioid neurotransmitters are especially active in Central Nervous System receptors, whose primary function is pain sensation.[3] These peptides all have the consensus amino acid sequence of Try-Gly-Gly-Phe-Met (met-enkephalin) or Tyr-Gly-Gly-Phe-Leu ( leu-enkephalin).[4] Binding of neoendorphins to opioid receptors (OPR), in the dorsal root ganglion (DRG) neurons results in the reduction of time of calcium-dependent action potential.[5] The α-neoendorphins bind OPRD1(delta), OPRK1(kappa), and OPRM1 (mu) and β-neoendorphin bind OPRK1.[6][7]

Types

Sequence Molecular Formula
α-neoendorphin
 H-Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys-OH C60H89N15O13
β-neoendorphin
 H-Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-OH C54H77N13O12

See also

  • Endorphin

References

  1. S2CID 33527743
    .
  2. PMID 6138396
    .
  3. ISBN 978-0-12-416687-5
    , retrieved 2022-04-24
  4. ISBN 978-0-12-095440-7
    , retrieved 2022-05-12
  5. S2CID 12991911
    .
  6. ^ PubChem. "beta-Neoendorphin". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-05-12.
  7. ^ PubChem. "alpha-Neoendorphin". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-05-12.


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