Neuregulin 4

Source: Wikipedia, the free encyclopedia.
NRG4
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_138573

NM_032002

RefSeq (protein)

NP_612640

NP_114391

Location (UCSC)Chr 15: 75.94 – 76.06 MbChr 9: 55.13 – 55.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[5][6][7]

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[7]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169752 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032311 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NRG4 neuregulin 4".
  6. PMID 12477932
    .
  7. ^ .
  8. .

Further reading