Neuregulin 4
NRG4 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 15: 75.94 – 76.06 Mb | Chr 9: 55.13 – 55.23 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[5][6][7]
Function
The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[7]
Clinical significance
Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169752 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032311 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: NRG4 neuregulin 4".
- PMID 12477932.
- ^ PMID 10348342.
- PMID 15583696.
Further reading
- Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP (January 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. PMID 17962208.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Hayes NV, Newsam RJ, Baines AJ, Gullick WJ (2008). "Characterization of the cell membrane-associated products of the Neuregulin 4 gene". Oncogene. 27 (5): 715–20. PMID 17684490.
- Hayes NV, Blackburn E, Smart LV, et al. (2007). "Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer". Clin. Cancer Res. 13 (11): 3147–55. PMID 17545517.