NeuroD
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Basic helix-loop-helix transcription factor
NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.[1] It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.[2]
In mammals there are two types of this factor:
References
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(4) β-Scaffold factors with minor groove contacts | |||||||||||||||||||
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(0) Other transcription factors | |||||||||
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