Neuropilin

Neuropilin
Crystallographic structure of the dimeric B1 domain of human neuropilin 1.[1]
Identifiers
Symbol	NRP
InterPro	IPR014648
Membranome	16

Neuropilin is a protein receptor active in neurons.

There are two forms of Neuropilins,

The pleiotropic nature of the NRP receptors results in their involvement in cellular processes, such as axon guidance and angiogenesis, the immune response and remyelination.^[10] Therefore, dysregulation of NRP activity has been implicated in many pathological conditions, including many types of cancer and cardiovascular disease.^{[11][12][13][14]}

Applications

Neuropilin-1 is a therapeutic target protein in the treatment for leukemia and lymphoma, since It has been shown that there is increased expression in neuropilin-1 in leukemia and lymphoma cell lines.^[15] Also, antagonism of neuropilin-1 has been found to inhibit tumour cell migration and adhesion.^[16]

Structure

Neuropilins contain the following four domains:

• N-terminal CUB domain (for complement C1r/C1s, Uegf, Bmp1)
• Coagulation factor 5/8 type, C-terminal (discoidin domain)
• MAM domain (for meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu)
• C-terminal neuropilin

The structure of B1 domain (coagulation factor 5/8 type) of neuropilin-1 was determined through X-Ray Diffraction with a resolution of 2.90 Å. The secondary structure of this domain is 5% alpha helical and 46% beta sheet.^[1]

Ramachandran plot.^[17]

References