Nialamide

Source: Wikipedia, the free encyclopedia.
Nialamide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • BR: Class C1 (Other controlled substances)[1]
Identifiers
  • N-benzyl-3-(N-(pyridine-4-carbonyl)hydrazino)propanamide
JSmol)
  • O=C(NNCCC(=O)NCc1ccccc1)c2ccncc2
  • InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22) checkY
  • Key:NOIIUHRQUVNIDD-UHFFFAOYSA-N checkY
  (verify)

Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective,

irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.[2] It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity.[3][4]

Side effects include agitation and insomnia, less frequently dry mouth, dizziness, blurred vision, and hypomania, and rarely leukopenia and hepatitis. As with other MAOIs, a hypertensive crisis can be triggered by co-ingestion of tyramine. It is metabolized into isoniazid, an anti-tuberculosis agent, and so is contraindicated in patients with tuberculosis. The recommended dosage range is 75 to 200 mg per day, with maintenance doses as low as 12.5 mg every other day.[5]

The antiatherogenic activity of nialamide was used to design pyridinolcarbamate.[6]

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ISBN 978-0-8155-1856-3
    .
  3. ISBN 978-1-4398-4567-7
    .
  4. ISBN 978-0-19-970933-5
    .
  5. LCCN 75147249
    . Retrieved April 5, 2021.
  6. PMID 4982663. Retrieved 3 October 2017. {{cite book}}: |journal= ignored (help
    )
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