Nicergoline

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Nicergoline
Clinical data
Trade namesSermion
Other names[(8β)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromopyridine-3-carboxylate
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Not recommended
Routes of
administration
By mouth, intramuscular, intravenous
ATC code
Legal status
Legal status
First-pass metabolism
Elimination half-life13–20 hours
Identifiers
  • [(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
JSmol)
  • Brc1cc(cnc1)C(=O)OC[C@@H]3C[C@]4(OC)c5cccc2c5c(cn2C)C[C@H]4N(C3)C
  • InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1 checkY
  • Key:YSEXMKHXIOCEJA-FVFQAYNVSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Nicergoline, sold under the brand name Sermion among others, is an

Parkinson's dementia. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs. Unlike many other ergolines, such as ergotamine, nicergoline is not associated with cardiac fibrosis.[2]

It is used for vascular disorders such as cerebral

.

Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.[3]

Medical uses

Nicergoline is used in the following cases:

  • Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis,
    Raynaud's disease
    and other syndromes caused by altered peripheral irrigation.
  • Migraines of vascular origin
  • Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension.
  • Corio-retinal vascular disorders: diabetic retinopathy, macular degeneration and retinal angiosclerosis
  • Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations,
    hypoacusis
    .

Dosages for known conditions are usually administered at 5–10 mg three times a day, however anti-aging preventative purposes may want to consider 5 mg once or twice a day more adequate.[4]

Contraindications

Persons suffering from acute bleeding, myocardial infarction (heart conditions), hypertension, bradycardia or using alpha or beta receptor agonists should consult with their physician before use. Although toxicology studies have not shown nicergoline to have any

teratogenic effect
, the use of this medicine during pregnancy should be limited to those cases where it is absolutely necessary.

On 28 June 2013, the

ergolines are associated with fibrosis and evidence suggests that nicergoline does not carry the same fibrotic risk like other ergoline derivatives such as ergotamine.[2]

Nicergoline is considered unsafe in porphyria.[6]

Side effects

The side effects of nicergoline are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness.[6] At high drug dosages, bradycardia, increased appetite, agitation, diarrhea and perspiration were reported. Most of the available literature suggests that the side effects of nicergoline are mild and transient.[2]

Interactions

Nicergoline is known to enhance the cardiac depressive effects of

xantinol nicotinate
.

Pharmacology

Pharmacodynamics

Nicergoline is an ergot alkaloid derivative that acts as a potent and selective

Society and culture

Generic names

Nicergoline is the

INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name, and DCFTooltip Dénomination Commune Française.[11][12]

References