Nicergoline
Clinical data | |
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Trade names | Sermion |
Other names | [(8β)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-bromopyridine-3-carboxylate |
AHFS/Drugs.com | International Drug Names |
Pregnancy category |
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Routes of administration | By mouth, intramuscular, intravenous |
ATC code | |
Legal status | |
Legal status |
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First-pass metabolism | |
Elimination half-life | 13–20 hours |
Identifiers | |
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JSmol) | |
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Nicergoline, sold under the brand name Sermion among others, is an
It is used for vascular disorders such as cerebral
Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.[3]
Medical uses
Nicergoline is used in the following cases:
- Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis, Raynaud's diseaseand other syndromes caused by altered peripheral irrigation.
- Migraines of vascular origin
- Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension.
- Corio-retinal vascular disorders: diabetic retinopathy, macular degeneration and retinal angiosclerosis
- Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations, hypoacusis.
Dosages for known conditions are usually administered at 5–10 mg three times a day, however anti-aging preventative purposes may want to consider 5 mg once or twice a day more adequate.[4]
Contraindications
Persons suffering from acute bleeding, myocardial infarction (heart conditions), hypertension, bradycardia or using alpha or beta receptor agonists should consult with their physician before use. Although toxicology studies have not shown nicergoline to have any
On 28 June 2013, the
Nicergoline is considered unsafe in porphyria.[6]
Side effects
The side effects of nicergoline are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness.[6] At high drug dosages, bradycardia, increased appetite, agitation, diarrhea and perspiration were reported. Most of the available literature suggests that the side effects of nicergoline are mild and transient.[2]
Interactions
Nicergoline is known to enhance the cardiac depressive effects of
Pharmacology
Pharmacodynamics
Nicergoline is an ergot alkaloid derivative that acts as a potent and selective
Society and culture
Generic names
Nicergoline is the
,References
- ^ https://www.ema.europa.eu/documents/psusa/nicergoline-list-nationally-authorised-medicinal-products-psusa/00002150/202005_en.pdf[bare URL PDF]
- ^ S2CID 22768662.
- PMID 11687175.
- ^ Nicergoline drug insert, Pharmacia & Upjohn, October 2000
- ^ European Medicines Agency (28 June 2013), "New restrictions on use of medicines containing ergot derivatives", Press Release
- ^ ISBN 978-0-85369-840-1.
- S2CID 43871763.
- PMID 2906797.
- PMID 9593228.
- S2CID 34963522.
- ISBN 978-1-4757-2085-3.
- ISBN 978-3-88763-075-1.