Nicholas Gonzalez (physician)

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Nicholas James Gonzalez (December 28, 1947 – July 21, 2015) was a

health fraud watchdog groups. In 1994 Gonzalez was reprimanded and placed on two years' probation by the New York state medical board for "departing from accepted practice".[1][3]

In one non-randomized clinical trial of terminally ill patients with pancreatic cancer, the Gonzalez-treated patients were found to have died much earlier than those treated with conventional chemotherapy. A better quality of life was reported by the chemotherapy arm.[5]

Biography

Gonzalez was born December 28, 1947, in

Prevention Magazine. Gonzalez became interested in medical research, cancer research in particular, while covering these topics.[7]

Gonzalez completed postgraduate premedical work at

All Children's Hospital in St. Petersburg, Florida.[3][7]

Gonzalez died of a suspected

heart attack on July 21, 2015, at age 67.[9][10] A conspiracy theory has subsequently spread that Gonzalez was murdered as part of a systematic plot to kill "holistic" practitioners.[9]

Cancer treatment and its effectiveness

Gonzalez's treatment methods, which he's been using since 1987, are developed from previous work by the orthodontist

National Center for Complementary and Alternative Medicine a clinical trial on Gonzalez's treatments produced "limited and inconclusive" results regarding the efficacy of the Gonzalez Regimen as a treatment for cancer.[11]

In 1999 Gonzalez published an article describing prolonged life in a small group of patients with pancreatic cancer in the peer-reviewed journal Nutrition and Cancer.[12] Subsequently, others concluded that the longer survival time reported by Gonzalez was due to selection bias and other confounds.[13][14]

Rejection by mainstream medicine

Like his mentor, William Donald Kelley, Gonzalez's treatment method has been "rejected" by the "medical establishment".

health fraud watchdog groups, and in 1994 was reprimanded and placed on two years' probation by the New York state medical board for "departing from accepted practice".[1][3] Forced to submit to psychological examinations and undergo retraining,[3] Gonzalez was given two years of probation with a stipulation that he undergo retraining and do 200 hours of community service, which he completed satisfactorily.[15] He was fully licensed to practice in New York.[16]

Gonzalez lost two

Hodgkin's lymphoma and ordered to pay $282,000 in damages, due to his use of an unproven cancer screening method instead of standard cancer testing.[23]

The American Cancer Society notes that there is "no convincing scientific evidence that [the Gonzalez treatment] is effective in treating cancer" and that some portions of the treatment may be harmful. A review article from the Journal of Clinical Gastroenterology is cited that notes the clinical efficacy of coffee enemas has not been proven and the therapy is associated with adverse effects previously described in a few case reports. Gonzalez's study published in Nutrition and Cancer in 1999 was criticized by an expert in integrative oncology research methods for its small sample size, selection bias, and failure to account for confounding variables.[13][14]

Gonzalez "never explicitly rejected the more orthodox precepts of his profession", insisting that he wanted his research evaluated by independent scientists.[3]

Clinical trial

A randomized phase III

National Center for Complementary and Alternative Medicine, and co-sponsored by the National Cancer Institute, awarded in 1999 to Columbia University's Rosenthal Center for Alternative Medicine.[3][11][24] The trial was designed to compare the efficacy of pancreatic enzyme therapy plus specialized diet with gemcitabine for stage II, stage III, or stage IV pancreatic cancer.[25] However, the study had difficulty attracting patients,[26] and most eligible patients refused random assignment, so the trial was changed in 2001 to a controlled, observational study.[27]

The trial found that patients treated with the Gonzalez regime survived on average for 4.3 months; those using standard chemotherapy survived on average for 14 months and reported a better quality of life.[5]

An accompanying editorial said it was troubling that expensive

CAM therapies were not backed by firm evidence, and that the trial of the Gonzalez regimen was not capable of providing a definitive conclusion because of flaws in its design.[28] Kimball Atwood said that flaws in the trial design might have led to bias in favor of the Gonzalez regimen but that it nevertheless amounted to "a slam-dunk condemnation" of the therapy.[29]

This trial had been criticized for its implausible and unsupported theoretical model of cancer development which bears no resemblance to the scientific understanding of

neoplasia,[24] and because of Gonzalez's history of malpractice.[19][30][31]

See also

  • List of ineffective cancer treatments

References

  1. ^ a b c d e "Maverick moves to mainstream". www.signonsandiego.com. Archived from the original on 23 June 2002. Retrieved 29 July 2008.
  2. PBS
    .
  3. ^ a b c d e f g h i Specter, M (2 May 2001). "The Outlaw Doctor; Cancer researchers used to call him a fraud. What's changed?". The New Yorker. p. 48.
  4. PMID 23251944
    .
  5. ^ a b "Gonzalez Regimen". National Cancer Institute. 24 May 2012.
  6. New York Times
    , 26 July 2015
  7. ^ a b "Nicholas James Gonzalez, M.D., curriculum vitae" (PDF). dr-gonzalez.com. Retrieved 30 August 2012.
  8. ^
    PMID 17283743
    .
  9. ^
    S2CID 133344385
    .
  10. ^ Lerner, M.D., Barron H. (14 January 2016). "Straddling Conventional and Alternative Cancer Treatment". The New York Times. Retrieved 25 May 2016.
  11. ^ a b c "Gonzalez Regimen". National Cancer Institute. 24 August 2005. Retrieved 29 July 2008.
  12. PMID 10368805
    .
  13. ^
    S2CID 35124492
    .
  14. ^ a b "Metabolic Therapy". American Cancer Society. 3 August 2012. Archived from the original on 25 April 2013. Retrieved 24 July 2015.
  15. ^ "Professional Misconduct and Professional Discipline: Nicholas Gonzalez, MD". 24 October 1994.
  16. ^ "Office of the Professions: Nicholas James Gonzalez License Information". New York State Education Department.
  17. ^ Charell v. Gonzalez, 660 N.Y.S. 2d 665 (Sup Ct., 1997).
  18. doi:10.1111/j.1571-9979.2004.00035.x
    .
  19. ^ a b "A cure for quacks". New Scientist. 22 August 1998.
  20. ^ a b "Cancer doc hit for $2.5M plus". New York Daily News. 31 March 1997. Archived from the original on 7 October 2008.
  21. Village Voice
    . 26 March 2002.
  22. ^ Gonzalez v. Ellenberg, 2004 NY Slip Op 51518(U) (NY 10/12/2004), 2004 NY Slip Op 51518 (NY, 2004), retrieved January 1, 2009
  23. ^ "Doctor liable in death of patient". New York Daily News. 21 April 2002.[permanent dead link]
  24. ^
    PMID 10986163
    .
  25. ^ "Gemcitabine Compared With Pancreatic Enzyme Therapy Plus Specialized Diet (Gonzalez Regimen) in Treating Patients Who Have Stage II, Stage III, or Stage IV Pancreatic Cancer". clinicaltrials.gov. 13 February 2013.
  26. ^ "Cancer's Enema No. 1? Make That 2", Wired, 30 October 2002
  27. PMID 19687327
    .
  28. PMID 20308650
    .
  29. ^ Atwood K (11 September 2009). "'Gonzalez Regimen' for Cancer of the Pancreas: Even Worse than We Thought (Part I: Results)". Science-Based Medicine.
  30. ^ Dreifus, C (3 April 2001). "A Conversation with Stephen Straus; Separating remedies from snake oil". The New York Times.
  31. S2CID 30481889
    .

Publications

External links
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