Nicotinic antagonist
A nicotinic antagonist is a type of
nicotine addiction.[medical citation needed
]
| Mechanism | Antagonist | Preferred receptor | Clinical use |
|---|---|---|---|
Ganglionic blocking agents
|
Hexamethonium | Ganglion type
|
None[2] |
| Mecamylamine | Ganglion type
|
||
Trimethaphan
|
Ganglion type
|
Rarely used for blood pressure decrease during surgery[2] | |
| Nondepolarizing neuromuscular blocking agents
|
Atracurium
|
Muscle type
|
anaesthesia[2]
|
Doxacurium
|
Muscle type
|
||
Mivacurium
|
Muscle type
|
||
Pancuronium
|
Muscle type
|
anaesthesia[2]
| |
Tubocurarine
|
Muscle type
|
Discovered in arrow poison it was the first pheripheral muscle relaxant. Rarely used since 1980s.[2] | |
Vecuronium
|
Muscle type
|
anaesthesia[2]
| |
| Depolarizing neuromuscular blocking agents
|
Succinylcholine* | Muscle type
|
|
| Centrally acting nicotinic antagonists | 18-Methoxycoronaridine | α3β4
|
|
| Bupropion | Antidepressant (NDRI) | ||
| Hydroxybupropion | Antidepressant (NDRI). Metabolite of bupropion. | ||
| Threohydrobupropion | α3β4 .
|
Antidepressant (NDRI). Metabolite of bupropion. | |
| Dextromethorphan | Common over the counter antitussive .
| ||
| Dextrorphan | Metabolite of dextromethorphan; no accepted medical uses. | ||
| 3-Methoxymorphinan | α3β4
|
Secondary metabolite of dextromethorphan; not used in medical practice. Unknown medical efficacy. |
- Note: neuromuscular blocking agentspage for details on the mechanism of action.
See also
- Nicotinic acetylcholine receptor
- Nicotinic agonist
- Muscarinic acetylcholine receptor
- Muscarinic agonist
- Muscarinic antagonist
References
- ^ P. Taylor (1990). In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th Ed., (A. G. Gilman et al., Eds.), pp. 166-186, New York: Pergamon Press.
- ^ ISBN 0-443-07145-4. Page 149
External links
Media related to Nicotinic antagonists at Wikimedia Commons- Nicotinic+antagonists at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
