Nicotinyl alcohol

Source: Wikipedia, the free encyclopedia.
Nicotinyl alcohol
Clinical data
Other namesRoniacol; Roniacol tartrate; Nicotinyl tartrate;[1] Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol
AHFS/Drugs.comMonograph
ATC code
Identifiers
  • (Pyridin-3-yl)methanol
JSmol)
  • OCc1cccnc1
  • InChI=1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2 ☒N
 ☒NcheckY (what is this?)  (verify)

Nicotinyl alcohol (pyridylcarbinol) is a

vasodilator. It causes flushing and may decrease blood pressure.[2]

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.[citation needed]

Buerger's disease),[5] arterial embolism, chilblains
or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication,[6] ulcer healing and others.[7]

Derivatives

At least a couple of uses for this agent were discovered over the years:

  1. Eniclobrate
  2. Mepiroxol
  3. Nicofibrate
  4. Pantenicate (Topanicate, MG 28362)

References

  1. PMID 14066712
    .
  2. ^ "Ronicol Retard". Medical Dictionary Online. 2012. Archived from the original on June 14, 2011. Retrieved July 27, 2012.
  3. PMID 14843421
    .
  4. ^ "Medical Dictionary, Dictionary of medicine and human biology, medical, biological and chemical terminology". www.theodora.com.
  5. ^ "Buergers disease by dr .ravinder narwal". July 7, 2011. page 18.
  6. PMID 13383231
    .
  7. .