Niementowski quinazoline synthesis
| Niementowski quinazoline synthesis | |
|---|---|
| Named after | Stefan Niementowski |
| Reaction type | Ring forming reaction |
The Niementowski quinazoline synthesis is the chemical reaction of anthranilic acids with amides to form 4-oxo-3,4-dihydroquinazolines (3H-quinazolin-4-ones).[1][2][3]
Uses
Research has demonstrated that the Niementowski quinazoline synthesis could be employed for the creation of potential
EGFR-inhibiting molecules. Hensbergen et al.[4]
have shown a synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring.
A nucleophilic aromatic substitution is combined with the Niementowski reaction and a BOP-mediated ring closure to afford several analogues.
References
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- John Wiley & Sons. pp. 324–376.
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- .