Nikethamide

Source: Wikipedia, the free encyclopedia.
Nikethamide
Clinical data
Other namesNicotinic acid diethylamide
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Elimination half-life0.5 h
Identifiers
  • N,N-Diethyl-3-pyridinecarboxamide
JSmol)
  • O=C(N(CC)CC)c1cccnc1
  • InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 checkY
  • Key:NCYVXEGFNDZQCU-UHFFFAOYSA-N checkY
  (verify)

Nikethamide is a

tranquilizer overdoses, before the advent of endotracheal intubation
and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.

In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.

Former and current medical use

Gertrude Hullett, whom he was suspected of murdering.[1] However, the toxicity of nikethamide is quite low (LD50
rabbits 650 mg/kg oral, LD50 rats 240 mg/kg subcutaneous).

Theodor Morell, Adolf Hitler's personal physician, would inject the German ruler with Coramine when Hitler was unduly sedated with barbiturates. In addition, Morell would use Coramine as part of an all-purpose "tonic" for Hitler.[2]

It is available as a short-acting

cardiovascular pathologies and epilepsy.[3]

Use in sports

In some sports, nikethamide is listed by the

kart driver Igor Walilko was given a two-year ban, later reduced to eighteen months, from competition in 2010 due to testing positive for nikethamide after a win in Germany in July, 2010.[7]

In July 2021, Swiss athlete and doctor Kariem Hussein was positively tested for nikethamide, which he regularly uses during training. He missed the 2020 Summer Olympics in Tokyo, and was banned from competitions for nine months.[8]

See also

References

  1. ISBN 1-904027-19-9
    .
  2. PMID 15825245
    .
  3. ^ Nikethamid Archived 2011-07-22 at the Wayback Machine, III-3.3, Toxcenter
  4. ^ "Olympic doping's list of shame". News24Wire ·. 24 August 2004.
  5. ^ "Marin Cilic: Croatian banned for nine months". BBC News. 16 September 2013. Retrieved 16 September 2013.
  6. ^ "Cilic cleared to play again after suspension reduced". Tennis. 25 October 2013. Retrieved 25 October 2013.
  7. ^ Walilko I (22 September 2011). "Decision of the Court of Arbitration for Sport" (PDF). FIA Anti-Doping Disciplinary Committee. Retrieved 23 July 2016.
  8. ^ "Diese Lutschtablette wurde Kariem Hussein zum Verhängnis". 20 Minuten (in German). 2021-07-23.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Nikethamide&oldid=1215135992"