Nitrendipine
Clinical data | |
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Trade names | Baypress |
AHFS/Drugs.com | International Drug Names |
Routes of administration | By mouth |
ATC code | |
Pharmacokinetic data | |
Bioavailability | 60–70% |
Protein binding | 98% |
Metabolism | Hepatic (completely) |
Onset of action | 1–2 hours |
Elimination half-life | 8–24 hours |
Excretion | Urine (30%) |
Identifiers | |
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JSmol) | |
Chirality | Racemic mixture |
Melting point | 158 °C (316 °F) |
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Nitrendipine is a
It was patented in 1971 and approved for medical use in 1985.[2]
Medical uses
Nitrendipine is given to hypertensive individuals in 20 mg oral tablets every day.
Mechanism of action
Once nitrendipine is ingested, it is absorbed by the gut and metabolized by the liver before it goes into the systemic circulation and reaches the cells of the
Nitrendipine has additionally been found to act as an
Stereochemistry
Nitrendipine contains a stereocenter and can exist as either of two
Enantiomers of Nitrendipine | |
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(R)-(+)-Nitrendipine CAS number: 80890-07-9 |
(S)-(-)-Nitrendipine CAS number: 80873-62-7 |
References
- S2CID 32137604.
- ISBN 9783527607495.
- ^ S2CID 46979688.
- ^ PMID 8621376.
- PMID 24992570.
- ISBN 978-3-946057-10-9, S. 204.