Noradrenergic and specific serotonergic antidepressant

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Noradrenergic and specific serotonergic antidepressants
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Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron)

Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of

serotonin receptors such as 5-HT2A and 5-HT2C,[1] but also 5-HT3,[1] 5-HT6, and/or 5-HT7 in some cases. By blocking α2-adrenergic autoreceptors and heteroreceptors, NaSSAs enhance adrenergic and serotonergic neurotransmission in the brain involved in mood regulation,[1] notably 5-HT1A-mediated transmission.[2] In addition, due to their blockade of certain serotonin receptors, serotonergic neurotransmission is not facilitated in unwanted areas, which prevents the incidence of many side effects often associated with selective serotonin reuptake inhibitor (SSRI) antidepressants;[1][3] hence, in part, the "specific serotonergic" label of NaSSAs.[2]

List of NaSSAs

The NaSSAs include the following agents:

Notably, all of these compounds are analogues and are also classified as tetracyclic antidepressants (TeCAs) based on their chemical structures.

preclinical research and may go on to undergo clinical trials
.

See also

References

  1. ^
    ISBN 978-0-7167-0615-1
    . Retrieved 23 April 2012.
  2. ^
    ISBN 978-1-58562-354-9
    . Retrieved 23 April 2012.
  3. ^ Bentham Science Publishers (August 1998). Current Pharmaceutical Design. Bentham Science Publishers. p. 298. Retrieved 23 April 2012.
  4. ^
    ISBN 978-0-8261-1094-7
    . Retrieved 23 April 2012.
  5. S2CID 8546314
    .
  6. S2CID 11363664
    .

Further reading

External links
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