Norepinephrine (medication)

Source: Wikipedia, the free encyclopedia.
This article is about the medication. For this substance as a naturally occurring hormone, see Norepinephrine.
Norepinephrine
Skeletal formula of noradrenaline
Ball-and-stick model of the zwitterionic form of noradrenaline found in the crystal structure[1]
Clinical data
Trade namesLevarterenol, Levophed, Norepin, other
Other namesNoradrenaline
(R)-(–)-Norepinephrine
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
COMT
Legal status
Legal status
COMT
ExcretionUrine (84–96%)
Identifiers
  • 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
JSmol)
Density1.397±0.06 g/cm3
Melting point217 °C (423 °F) (decomposes)
Boiling point442.6 °C (828.7 °F) ±40.0°C
  • Oc1ccc(cc1O)[C@@H](O)CN
  • InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 checkY
  • Key:SFLSHLFXELFNJZ-QMMMGPOBSA-N checkY
  (verify)

Norepinephrine, also known as noradrenaline, is a

intravenous fluids.[3] It is the same molecule as the hormone and neurotransmitter norepinephrine.[2] It is given by slow injection into a vein.[2]

Common side effects include headache, slow heart rate, and

alpha adrenergic receptors.[2]

Norepinephrine was discovered in 1946 and was approved for medical use in the United States in 1950.

generic medication.[2]

Medical uses

Norepinephrine is used mainly as a sympathomimetic drug to treat people in vasodilatory shock states such as septic shock and neurogenic shock, while showing fewer adverse side-effects compared to dopamine treatment.[5][6]

Mechanism of action

It stimulates

peripheral vascular resistance and resulted in increased blood pressure. This effect also reduces the blood supply to gastrointestinal tract and kidneys. Norepinephrine acts on beta-1 adrenergic receptors, causing increase in heart rate and cardiac output.[7] However, the elevation in heart rate is only transient, as baroreceptor response to the rise in blood pressure as well as enhanced vagal tone ultimately result in a sustained decrease in heart rate.[8] Norepinephrine acts more on alpha receptors than the beta receptors.[9]

Names

Norepinephrine is the

INN while noradrenaline is the BAN
.

References

  1. PMID 1202890
    .
  2. ^ a b c d e f g h i j "Norepinephrine Bitartrate". The American Society of Health-System Pharmacists. Archived from the original on 26 March 2017. Retrieved 26 March 2017.
  3. ISBN 9783319298245. Archived
    from the original on 2017-03-27.
  4. ISBN 9780123851581. Archived
    from the original on 2017-03-27.
  5. S2CID 52827184
    . We recommend norepinephrine as the first-choice vasopressor (strong recommendation, moderate quality of evidence).
  6. PMID 20200382
    .
  7. ISBN 9781468405248
    . Retrieved 19 November 2017.
  8. ^ Klabunde RE (7 December 2022). "Circulating Catecholamines". CV Physiology. Retrieved 2019-02-27.
  9. PMID 26185405
    .

External links
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