Norepinephrine reuptake inhibitor

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Norepinephrine Reuptake Inhibitor
)
Norepinephrine reuptake inhibitor
Drug class
Synonymsadrenergic reuptake inhibitor
External links
MeSHD018759
Legal status
In Wikidata
Norepinephrine
Epinephrine

A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of

extracellular concentrations of norepinephrine and epinephrine and therefore can increase adrenergic neurotransmission
.

Medical use

NRIs are commonly used in the treatment of conditions like

NDRIs) to produce rewarding effects in psychostimulant addictive substances.[3]

Depression

A meta analysis published in BMJ in 2011 concluded that the selective NRI reboxetine is indistinguishable from placebo in the treatment of depression.[4] A second review by the European Medicines Agency concluded that reboxetine was significantly more effective than placebo, and that its risk/benefit ratio was positive. The latter review, also examined the efficacy of reboxetine as a function of baseline depression, and concluded that it was effective in severe depression and panic disorder but did not show effects significantly superior to placebo in mild depression.[5]

A closely related type of drug is a norepinephrine releasing agent (NRA).

List of selective NRIs

Noradrenaline
(norepinephrine) transporter inhibitors

Many NRIs exist, including the following:

Note: Only NRIs selective for the NET greater than the other two

SNDRI
.

See also

References

  1. PMID 15283948
    .
  2. PMID 15526000
    .
  3. S2CID 15573624
    .
  4. PMID 20940209
    .
  5. ^ "MHRA Public Assessment Report" (PDF). Archived from the original (PDF) on 2014-04-27. Retrieved 2014-04-26.
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