Norepinephrine releasing agent
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Norepinephrine releasing agents
)
A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a
extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission.[1][2]
A closely related type of drug is a
adrenergic receptor agonist
class.
Uses and examples
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NRAs are used for a variety of clinical indications including the following:
- For the treatment of attention deficit hyperactivity disorder (ADHD) — e.g., amphetamine, methamphetamine, pemoline
- As anorectics in the treatment of obesity — e.g., amphetamine, phentermine, benzphetamine, phenmetrazine, aminorex
- As wakefulness-promoting agents in the treatment of narcolepsy— e.g., amphetamine, methamphetamine
- As nasal decongestants — e.g., levomethamphetamine, propylhexedrine, ephedrine, pseudoephedrine, phenylpropanolamine
They are also used as
4-methylaminorex, among others.[3]
Catha edulis. Ephedrine and pseudoephedrine are also found naturally in Ephedra sinica. Both of these plants are used medicinally (and recreationally as well regarding the former). The endogenous trace amines phenethylamine and tyramine
are NRAs found in many animals, including humans.
Selective NRAs include ephedrine, pseudoephedrine, phenylpropanolamine, levomethamphetamine, phentermine, and bupropion. These drugs also release dopamine to a much lesser extent, however, and bupropion is also a nicotinic acetylcholine receptor antagonist.
See also
References
- ISBN 0-07-142280-3. Archived from the originalon 2011-11-18. Retrieved 2011-06-26.
- ]
- ISSN 0956-7135.
External links
Media related to Norepinephrine releasing agents at Wikimedia Commons
