Norman Heatley
Norman Heatley | |
---|---|
Born | Woodbridge, Suffolk, England | 10 January 1911
Died | 5 January 2004 Oxford, England | (aged 92)
Nationality | English |
Education | Saint Felix School; Westbourne House School; Tonbridge School |
Alma mater | St John's College, Cambridge |
Known for | Penicillin |
Scientific career | |
Fields | Biology, biochemistry |
Institutions | Lincoln College, Oxford University |
Norman George Heatley
Heatley developed the back-extraction technique for efficiently purifying penicillin in bulk.Early life
He was born in Woodbridge, Suffolk, and as a boy was an enthusiastic sailor of a small boat on the River Deben, an experience which gave him a lifelong love of sailing. He attended school at Westbourne House in Folkestone, followed by Tonbridge School, then went on to St John's College, Cambridge, where he studied Natural Sciences, graduating in 1933. His doctoral research in Cambridge led to a PhD in 1936, and he then moved to the University of Oxford, where he became a fellow of Lincoln College and joined a team working under Howard Florey that included Ernst Chain.[4]
Production problem
Heatley recorded these trials, carried out on eight mice in May 1940, in his diary:[citation needed]
"After supper with some friends, I returned to the lab and met the professor to give a final dose of penicillin to two of the mice. The 'controls' were looking very sick, but the two treated mice seemed very well. I stayed at the lab until 3:45 a.m., by which time all four control animals were dead."
On returning home, he realised that in haste and darkness, he had put his underpants on back to front, and noted this in his diary too, adding "It really looks as if penicillin may be of practical importance." In order to conduct tests on human patients, even more of the drug had to be produced, and again it was Heatley who realised that the most effective vessel for this purpose was something like the porcelain bedpans in use at the Radcliffe Infirmary. These were in short supply because the ongoing World War II, so Heatley designed a modified version which was manufactured in the Potteries. With the help of these, the Oxford laboratory became the first penicillin factory, and subsequent tests on humans proved the efficacy of the new treatment. Even so, it was very difficult to produce enough for sustained treatment.[4]
Trials on humans
In December 1940, a 43-year-old police constable,
Illinois and New Jersey
Eventually, Heatley and Florey travelled to the United States in 1941 because they wanted to produce about one kilogram of pure penicillin, and persuaded a laboratory in Peoria, Illinois, to develop larger-scale manufacturing of it. In Peoria, Heatley was assigned to work with Dr. A.J. Moyer. Moyer suggested adding corn-steep liquor, a by-product of starch extraction, to the growth medium. With this and other subtle changes, such as using lactose in place of glucose, they were able to push up yields of penicillin to 20 units per millilitre. But their cooperation had become one-sided. Heatley noted, "Moyer had begun not telling me what he was doing."[9]
Florey returned to Oxford that September, but Heatley stayed on in Peoria until December; then for the next six months, he worked at Merck & Co. in Rahway, New Jersey. In July 1942, he returned to Oxford and was soon to learn why Moyer had become so secretive. When he published their research results, he omitted Heatley's name from the paper, despite an original contract which stipulated that any publications should be jointly authored. Fifty years on, Heatley confessed that he was amused, rather than upset, by Moyer's duplicity. Later he was to learn that financial greed had led Moyer to claim all the credit for himself. To have acknowledged Heatley's part of the work would have made it difficult to apply for patents, as he did, with himself as sole inventor.[4]
Achievement
As Sir Henry Harris put it succinctly in 1998:[citation needed]
"Without Fleming, no Chain or Florey; without Florey, no Heatley; without Heatley, no penicillin."
Yet while Fleming, Florey and Chain jointly received the
Final years
Heatley died on 5 January 2004 at his home, 12 Oxford Road,
Legacy
After Heatley died in 2004, Oxford University established a Norman Heatley Postdoctoral Award for researchers showing excellent ingenuity and problem-solving skills.[11] Heatley's papers are archived within the Wellcome Collection in London.[12]
References
- ^ White, Pearce (7 February 2004). "Obituary: Norman George Heatley" (PDF). The Lancet. 363: 495. Retrieved 2 December 2023.
- ^ "Obituary: Norman Heatley – Research biochemist who secured the development of penicillin". The Times. 7 January 2004. Retrieved 2 December 2023.
- ^ "Obituaries: Norman Heatley – Last survivor of the team that developed penicillin". The Independent. 23 January 2004. Retrieved 2 December 2023.
- ^ a b c d Evans, Ruth (8 January 2004). "Obituary: Norman Heatley". The Guardian. Retrieved 4 August 2006.
- ISBN 978-0-525-53885-1.
- ^ a b "Making Penicillin Possible: Norman Heatley Remembers". ScienceWatch. Thomson Scientific. 2007. Archived from the original on 21 February 2007. Retrieved 13 February 2007.
- ^ "Discovery and development of penicillin". American Chemical Society. 1999.
- ^ "Penicillin – the miracle mould" (PDF). Marvellous micro-organisms. Australian Academy of Science. Archived from the original (PDF) on 6 September 2006. Retrieved 13 February 2007.
- ^ "Making Penicillin Possible: Norman Heatley Remembers". ScienceWatch. Archived from the original on 30 June 2012. Retrieved 28 December 2018.
- Oxford Today: The University Magazine. 16 (3). Archived from the originalon 9 October 2006. Retrieved 4 August 2006.
(1990 Oxford: an Honorary Doctorate in Medicine, the first given to a non-medic in Oxford's 800-year history and, in Heatley's view, 'an enormous privilege, since I am not medically qualified')
- ^ a b c "Norman HEATLEY (1911–2004), Biochemist, key member of the Oxford penicillin team". Oxfordshire Blue Plaques Scheme. UK: Oxfordshire Blue Plaques Board. 17 July 2010. Retrieved 2 December 2023.
- ^ "Heatley, Norman George, OBE (1911–2004)". Collections. London, UK: Wellcome Collection. Retrieved 2 December 2023.
Sources
- Heatley, Norman George, Oxford Dictionary of National Biography(restricted access)