Norsalsolinol
Names | |
---|---|
Preferred IUPAC name
1,2,3,4-Tetrahydroisoquinoline-6,7-diol | |
Other names
6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
| |
Identifiers | |
3D model (
JSmol ) |
|
ChEBI | |
ChemSpider | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C9H11NO2 | |
Molar mass | 165.189 g/mol |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
|
Neurotoxin |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Norsalsolinol is a chemical compound that is produced naturally in the body through metabolism of dopamine.[1] It has been shown to be a selective dopaminergic neurotoxin,[2][3][4] and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease and the brain damage associated with alcoholism,[5][6] although evidence for a causal relationship is unclear.[7][8][9]
(R)-Salsolinol which has been shown to be a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake in rats[10]
See also
References
- PMID 8093579.
- PMID 11411492.
- S2CID 38150947.
- PMID 19012744.
- PMID 8420138.
- S2CID 76761.
- PMID 14528920.
- PMID 15026514.
- PMID 15654290.
- ^ "(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. | PubFacts.com". www.pubfacts.com. Retrieved 2017-10-02.