Nucleoporin 107
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Location (UCSC) | Chr 12: 68.69 – 68.75 Mb | Chr 10: 117.59 – 117.63 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.[5][6][7]
Function
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]
Interactions
NUP107 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111581 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052798 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 12552102.
- S2CID 16449133.
- ^ a b "Entrez Gene: NUP107 nucleoporin 107kDa".
- PMID 15146057.
- PMID 11564755.
Further reading
- Bastos R, Ribas de Pouplana L, Enarson M, Bodoor K, Burke B (Jun 1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". The Journal of Cell Biology. 137 (5): 989–1000. PMID 9166401.
- Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. PMID 11564755.
- Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology. 155 (3): 339–54. PMID 11684705.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. PMID 12477932.
- Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M (Aug 2003). "RanGTP mediates nuclear pore complex assembly". Nature. 424 (6949): 689–94. S2CID 4423987.
- Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. PMID 15146057.
- Krull S, Thyberg J, Björkroth B, Rackwitz HR, Cordes VC (Sep 2004). "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket". Molecular Biology of the Cell. 15 (9): 4261–77. PMID 15229283.
- Berke IC, Boehmer T, Blobel G, Schwartz TU (Nov 2004). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". The Journal of Cell Biology. 167 (4): 591–7. PMID 15557116.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. PMID 16565220.
- Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ (Sep 2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Molecular Biology of the Cell. 17 (9): 3806–18. PMID 16807356.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT (Mar 2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proceedings of the National Academy of Sciences of the United States of America. 104 (10): 3811–6. PMID 17360435.
- Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V (Apr 2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". The EMBO Journal. 26 (7): 1853–64. PMID 17363900.
- Boehmer T, Schwartz TU (Sep 2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallographica Section F. 63 (Pt 9): 816–8. PMID 17768364.