Nucleoprotein

Source: Wikipedia, the free encyclopedia.
Not to be confused with Nuclear protein.
A nucleosome is a combination of DNA + histone proteins.

Nucleoproteins are

nucleocapsid
proteins.

Structures

Ebola virus
particle, with structures of the major proteins shown and labelled on the right

Nucleoproteins tend to be positively charged, facilitating interaction with the negatively charged nucleic acid chains. The

cryo-electron microscopy
.

Viruses

Lassa.[11]

Deoxyribonucleoproteins

A deoxyribonucleoprotein (DNP) is a complex of DNA and protein.[12] The prototypical examples are nucleosomes, complexes in which genomic DNA is wrapped around clusters of eight histone proteins in eukaryotic cell nuclei to form chromatin. Protamines replace histones during spermatogenesis.

Functions

The most widespread deoxyribonucleoproteins are

eukaryotes consists of such nucleoproteins.[2][13]

In eukaryotic cells, DNA is associated with about an equal mass of histone proteins in a highly condensed nucleoprotein complex called chromatin.[14] Deoxyribonucleoproteins in this kind of complex interact to generate a multiprotein regulatory complex in which the intervening DNA is looped or wound. The deoxyribonucleoproteins participate in regulating DNA replication and transcription.[15]

Deoxyribonucleoproteins are also involved in

Rad51 and Dmc1 recombinases).[18]

Ribonucleoproteins

Main article: Heterogeneous ribonucleoprotein particle
See also: RNP world
transcribe
RNA. At this point, once the virus enters a host cell it will be prepared to begin the process of replication.

Anti-RNP antibodies

Anti-RNP antibodies are

Anti-Smith antibodies and are specific for SLE. The presence of a significant level of anti-U1-RNP also serves a possible indicator of MCTD when detected in conjunction with several other factors.[28]

Functions

The ribonucleoproteins play a role of protection.

mRNAs never occur as free RNA molecules in the cell. They always associate with ribonucleoproteins and function as ribonucleoprotein complexes.[14]

In the same way, the genomes of negative-strand RNA viruses never exist as free RNA molecule. The ribonucleoproteins protect their genomes from

antigenic determinants
.

See also

References

  1. ^ Nucleoproteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  2. ^
    ISBN 0-12-361811-8
    .
  3. ISBN 978-3-540-68637-8
    .
  4. PMID 12609865
    .
  5. PMID 15556983
    .
  6. S2CID 610062
    .
  7. S2CID 29937744
    .
  8. ^
    PMID 23595147
    .
  9. PMID 26715309
    .
  10. PMID 22875964
    .
  11. PMID 21085117
    .
  12. ^ Deoxyribonucleoproteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  13. ISBN 978-1-4641-0962-1
    .
  14. ^ a b Lodish, Harvey. Molecular Cell Biology.
  15. PMID 2203758
    .
  16. PMID 9573041
    .
  17. S2CID 4427794
    .
  18. PMID 29382724
    .
  19. PMID 25965334
    .
  20. PMID 18959479
    .
  21. PMID 18597886
    .
  22. ^ "Ribonucleoprotein". www.uniprot.org. Retrieved 2016-11-07.
  23. ^ Bank, RCSB Protein Data. "RCSB Protein Data Bank - RCSB PDB". Archived from the original on 2015-04-18. Retrieved 2018-04-14. {{cite journal}}: Cite journal requires |journal= (help)
  24. PMID 21071426
    .
  25. S2CID 37061678
    .
  26. PMID 21731653
    .
  27. PMID 8039508
    .
  28. ^ "Mixed Connective Tissue Disease (MCTD) | Cleveland Clinic". my.clevelandclinic.org. Retrieved 2016-11-07.
  29. PMID 21824806
    .

External links
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