OAS1

Source: Wikipedia, the free encyclopedia.
OAS1
Available structures
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001032409
NM_002534
NM_016816
NM_001320151

NM_145211

RefSeq (protein)

NP_001027581
NP_001307080
NP_002525
NP_058132

NP_660212

Location (UCSC)Chr 12: 112.91 – 112.93 MbChr 5: 121.03 – 121.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.[5][6]

This gene encodes a member of the

innate immune response
to viral infection.

The encoded protein is induced by

RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Hypomorphic mutations in this gene have been associated with host susceptibility to viral infection, while gain-of-function variants can cause autoinflammatory immunodeficiency.[7] Alternatively spliced transcript variants encoding different isoforms have been described.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089127 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052776 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 9344649
    .
  6. .
  7. .
  8. ^ "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa".

Further reading


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