ORF3a
| Betacoronavirus viroporin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | bCoV_viroporin | ||||||||
| Pfam | PF11289 | ||||||||
| InterPro | IPR024407 | ||||||||
| |||||||||
ORF3a (previously known as X1 or U274)
Comparative genomics
ORF3a is well
Although ORF3a is present in
Structure
The ORF3a protein is a
Post-translational modifications
In SARS-CoV,
Expression and localization
Genomic organisation of isolate Wuhan-Hu-1, the earliest sequenced sample of SARS-CoV-2, indicating the location of ORF3a | |
| NCBI genome ID | 86693 |
|---|---|
| Genome size | 29,903 bases |
| Year of completion | 2020 |
| Genome browser (UCSC) | |
Along with the genes for other accessory proteins, the ORF3a gene is located near those encoding the structural proteins, at the
Function
The ORF3a protein does not appear to be essential for viral replication. From studies with SARS-CoV, there is conflicting evidence on whether or not its deletion reduces replication efficiency.[3][2]
Viroporin
The ORF3a protein is thought to form a
Viral protein interactions
The ORF3a protein in SARS-CoV has been shown to form
Host cell effects
A number of effects of ORF3a on the host cell have been described under experimental conditions. ORF3a has been associated with induction of apoptosis in studies of both SARS-CoV and SARS-CoV-2 in cell culture.[3][2][4]
Immunogenicity
The ORF3a protein is
