ORF7b
| Betacoronavirus NS7B protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | bCoV_NS7B | ||||||||
| Pfam | PF11395 | ||||||||
| InterPro | IPR021532 | ||||||||
| |||||||||
ORF7b is a
Structure
ORF7b protein is a
sequence identity.[2]
Expression and localization
ORF7b is an
subgenomic RNA through leaky scanning.[1] In SARS-CoV, it is localized to the Golgi apparatus, which requires the transmembrane helix sequence.[1][4] In SARS-CoV-2, it has been reported to associate with the endoplasmic reticulum.[5]
Function
The function of the ORF7b protein is not well characterized. It is not
deletion mutation in the ORF7b region, resulting in a fusion protein between ORF7b and ORF8, has been identified, of unclear significance.[2][8]
