ORF8
| Betacoronavirus NS8 protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | bCoV_NS8 | ||||||||
| Pfam | PF12093 | ||||||||
| InterPro | IPR022722 | ||||||||
| |||||||||
ORF8 is a
Structure
ORF8 in SARS-CoV-2 encodes a protein of 121
ORF8 in SARS-CoV and SARS-CoV-2 are very divergent, with less than 20%
Post-translational modifications
The full-length SARS-CoV ORF8ab protein is
Expression and localization
Along with the genes for other accessory proteins, the ORF8 gene is located near those encoding the structural proteins, at the
There are variable reports in the literature regarding the localization of SARS-CoV ORF8a, ORF8b, or ORF8ab proteins.[6] It is unclear if ORF8b is expressed at significant levels under natural conditions.[10][12] The full-length ORF8ab appears to localize to the ER.[12]
Function
The function of the ORF8 protein is unknown. It is not essential for viral replication in either SARS-CoV[6] or SARS-CoV-2,[4] though there is conflicting evidence on whether loss of ORF8 affects the efficiency of viral replication.[13]
A function often suggested for ORF8 protein is interacting with the host
It has been suggested that the SARS-CoV ORF8a protein assembles into multimers and forms a viroporin.[17]
Evolution
The
In SARS-CoV, the ORF8 region is thought to have originated through
ORF8 encodes a protein whose
References
- ^ PMID 33361333.
- ^ PMID 32471829.
- ^ PMID 33685621.
- ^ PMID 34305949.
- ^ PMID 27743750.
- ^ PMID 24995382.
- ^ PMID 33392262.
- ^ PMID 33468697.
- PMID 17520018.
- ^ PMID 17928347.
- PMID 33203855.
- ^ PMID 23202509.
- ^ PMID 32825438.
- S2CID 221136730.
- PMID 36198800.
- S2CID 252737550.
- PMID 20708597.
- PMID 33615195.
- ^ PMID 32890763.
- PMID 26269185.
- PMID 29190287.
