ORF9c
| Betacoronavirus uncharacterised protein 14 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | bCoV_Orf14 | ||||||||
| Pfam | PF17635 | ||||||||
| InterPro | IPR035113 | ||||||||
| |||||||||
ORF9c (formerly also called ORF14) is an
protein-coding gene.[3]
Nomenclature
There has been inconsistency in the nomenclature used for this gene in the scientific literature. In some work on
SARS-CoV, it has been referred to as ORF14.[4] It has sometimes been referred to as ORF9b, while its longer upstream neighbor ORF9b was given the name ORF9a. The current recommended nomenclature refers to this gene as ORF9c, and the upstream gene as ORF9b.[2]
Expression and interactions
ORF9c is one of two
NF-kB pathway.[1][6] The SARS-CoV protein forms self-interactions suggesting protein dimer or higher-order oligomer formation.[7]
Evolution
ORF9c has about 74%
sequence identity between SARS-CoV and SARS-CoV-2.[1]
