Olanzapine/fluoxetine

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Olanzapine/fluoxetine
Combination of
OlanzapineAtypical antipsychotic
FluoxetineSelective serotonin reuptake inhibitor
Clinical data
Trade namesSymbyax, Cinol Forte, Olapin Forte, others
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
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Olanzapine/fluoxetine (trade name Symbyax, created by

fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder[2] as well as treatment-resistant depression.[1][3]

Medical uses

Olanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003.[1] In 2009, it was granted approval for the treatment of treatment-resistant depression.[4]

Olanzapine/fluoxetine, or other

posttraumatic stress disorder (PTSD).[8]

Side effects

Possible side effects of olanzapine/fluoxetine include all those of the two component drugs:

fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating.[1]

Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine.[9]

Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring.[9]

In rare cases, olanzapine/fluoxetine may cause neuroleptic malignant syndrome.[1]

Like other SSRIs, olanzapine/fluoxetine carries a boxed warning stating that it could increase the risk of suicidal thoughts and behaviors in patients aged 24 and under. The warning also states that olanzapine/fluoxetine may increase the risk of death in elderly patients with dementia-related psychosis.[1]

See also

References

  1. ^ a b c d e f "Symbyax- olanzapine and fluoxetine hydrochloride capsule". DailyMed. 21 April 2020. Retrieved 30 September 2020.
  2. ^ "Tratamento medicamentoso dos transtornos bipolares - Transtornos psiquiátricos". Manuais MSD edição para profissionais (in Brazilian Portuguese). Retrieved 2022-10-02.
  3. PMID 19906346
    .
  4. ^ Grohol, J. "FDA Approves Symbyax for Treatment Resistant Depression". Psych Central Blog. Archived from the original on 2017-12-26. Retrieved 2010-07-17.
  5. PMID 14700010
    .
  6. S2CID 38506292
    .
  7. PMID 10937610
    .
  8. PMID 12359687
    .
  9. ^ a b "Symbyax". Drugs.com.

External links