ORG-26576

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(Redirected from
Org 26576
)
ORG-26576
Identifiers
  • (9aS)-8,9,9a,10-Tetrahydro-5H,7H-pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one
JSmol)
  • C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
  • InChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1
  • Key:FIKUEZUFASUKAH-QMMMGPOBSA-N

ORG-26576 is an

Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays.[1][2][3][4][5][6] Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.[7]

See also

References