Orosomucoid

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Chr. 9 q31-qter
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orosomucoid 2
Identifiers
SymbolORM2
Chr. 9 q31-qter
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Orosomucoid (ORM) or alpha-1-acid glycoprotein (α1AGp,

alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL (1–3% plasma protein).[2] Plasma levels are affected by pregnancy, burns, certain drugs, and certain diseases, particularly HIV.[2]

The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic (negatively charged) drugs (whereas

cyclic AMP. High AGP concentrations, however, inhibited TSH signalling.[5][6]

Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five-year risk of all-cause mortality (the other three are

citrate).[7]

Orosomucoid increases in amount in obstructive

intestinal infections.[citation needed
]

See also

References

  1. ISBN 0-397-54589-4
    .
  2. ^
    S2CID 684478
    .
  3. PMID 1741754
    .
  4. ISBN 978-0-7817-8763-5
    .
  5. S2CID 22815279
    .
  6. PMID 23365787
    .
  7. PMID 24586121
    .

External links
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