Osteosclerosis
| Osteosclerosis | |
|---|---|
 | |
| Sclerosis of the bones of the pelvis due to prostate cancer metastases | |
| Specialty | Medical genetics  |
Osteosclerosis is a disorder that is characterized by
sickle-cell disease and osteoarthritis among others. Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary.[2][1]
Types
Acquired osteosclerosis
- Osteogenic bone metastasis caused by carcinoma of prostate and breast
- Paget's disease of bone
- Myelofibrosis(primary disorder or secondary to intoxication or malignancy)
- Osteosclerosing types of chronic osteomyelitis
- Hypervitaminosis D
- hyperparathyroidism
- Schnitzler syndrome[3]
- Mastocytosis[4]
Hereditary osteosclerosis
- Malignant infantile osteopetrosis[7]
- Neuropathic infantile osteopetrosis
- Infantile osteopetrosis with renal tubular acidosis
- Infantile osteopetrosis with immunodeficiency
- IO with leukocyte adhesion deficiency syndrome(LAD-III)
- Intermediate osteopetrosis
- Autosomal dominant osteopetrosis (Albers-Schonberg)
- Pyknodysostosis (osteopetrosis acro-osteolytica)[2]
- Osteopoikilosis (Buschke–Ollendorff syndrome)[2]
- Osteopathia striata with cranial sclerosis[2]
- Mixed sclerosing bone dysplasia
- Progressive diaphyseal dysplasia (Camurati–Engelmann disease)[2]
- SOST-related sclerosing bone dysplasias
-
Sclerosis of the bones of the thoracic spine due to prostate cancer metastases (CT image) -
Sclerosis of the bones of the thoracic spine due to prostate cancer metastases (CT image)
Diagnosis
Osteosclerosis can be detected with a simple radiography. There are white portions of the bone which appear due to the increased number of bone trabeculae.[citation needed]
Animals
In the animal kingdom, there also exists a non-pathological form of osteosclerosis, resulting in unusually solid bone structure with little to no marrow. It is often seen in aquatic
vertebrates, especially those living in shallow waters,[8] providing ballast as an adaptation for an aquatic lifestyle. It makes bones heavier, but also more fragile. In those animal groups, osteosclerosis often occurs together with bone thickening (pachyostosis). This joint occurrence is called pachyosteosclerosis.[9]
See also
References
- ^ PMID 28326337.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - ^ PMID 22084176.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - S2CID 1597002.
- S2CID 51628281.
- PMID 7938961.
- S2CID 39008572.
- doi:10.1016/j.ejrnm.2016.12.013.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - ^ Houssaye, A. (2009). "Pachyostosis" in aquatic amniotes: a review. Integrative Zoology 4(4): 325-340.
- S2CID 218789355.