Oxaprotiline

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Oxaprotiline
Clinical data
Routes of
administration		Oral
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (±)-3-(9,10-ethano-9,10-dihydro-9-anthryl)-1-methylamino-2-propanol
JSmol)
  • CNCC(CC12CCC(C3=CC=CC=C31)C4=CC=CC=C24)O
  • InChI=1S/C20H23NO/c1-21-13-14(22)12-20-11-10-15(16-6-2-4-8-18(16)20)17-7-3-5-9-19(17)20/h2-9,14-15,21-22H,10-13H2,1H3 checkY
  • Key:FDXQKWSTUZCCTM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Oxaprotiline (developmental code name C 49-802 BDA), also known as hydroxymaprotiline, is a norepinephrine reuptake inhibitor belonging to the tetracyclic antidepressant (TeCA) family and is related to maprotiline. Though investigated as an antidepressant,[1] it was never marketed.

Pharmacology

Dextroprotiline acts as a

D2 receptors like its relative maprotiline
is unclear.

Levoprotiline acts as a

serotonin receptors, or any of the monoamine transporters.[2][3][4]

Chemistry

Oxaprotiline is a

levo- oxaprotiline (levoprotiline; CGP-12,103-A), and S(+)- or dextro- oxaprotiline (dextroprotiline; CGP-12,104-A). Both enantiomers are active, with the levo- form acting as an antihistamine and the dextro- form having an additional pharmacology (see above), but with both unexpectedly still retaining antidepressant effects.[6]

See also

References

  1. S2CID 24152419
    .
  2. ^
    PMID 7115436
    .
  3. ^
    S2CID 22691825
    .
  4. ^
    S2CID 29562845
    .
  5. ^
    PMID 6086881
    .
  6. PMID 1530672
    .