Oxford Vaccine Group
Professor Andrew J Pollard | |
Parent organization | University of Oxford |
---|---|
Affiliations | UKCRC registered |
Staff | 75 |
Website | www |
The Oxford Vaccine Group (OVG) is a vaccine research group within the Department of
OVG came to public prominence in 2020 for the vaccine it created to combat COVID-19.
Aims and background
OVG carries out research on vaccines to improve human health. It works to enhance the understanding of
OVG is a research group within the Department of Paediatrics at the
Professor Andrew Pollard, OVG’s Director, was appointed Chair of the
Research activity
Since 2001, OVG has enrolled over 12,500 adults and children into clinical trials in the Thames Valley area of England. OVG research has included:
- 2003: a study looking at the mid- to long-term effectiveness of the Meningitis C vaccine.[13][14] This research showed that immunity waned over time, and formed part of the evidence leading to the changes in the UK MenC vaccine schedule in 2013.[15][16]
- 2005 onwards: collaborative projects with the paediatric department of typhoid, Haemophilus influenzae type b (Hib disease) and pneumonia, and evaluating carriage of Hib disease and Streptococcus pneumoniae.
- 2006: a study looking at the effectiveness of a new vaccine against the bird flu virus
- 2006: a phase II trial of a new vaccine against MenB disease.Bexsero, in 2013.[3]
- 2009: a study comparing the effectiveness of two new vaccines against the swine flu virus
- 2010: a study of a new quadrivalent meningococcal (MenACWY) vaccine.[23]
- 2011 onwards: Ongoing participation in an EU Childhood Life-threatening Infectious Disease Study (EUCLIDS) work package looking at genetic responses to MenC and MenB vaccines.[24]
- 2011 onwards: a series of challenge studies to test new vaccines against typhoid and paratyphoid fever.
- 2014-15: a phase 1 study into a new vaccine against Ebola.[25][26] In January 2015 this trial was commended in the House of Commons by Nicola Blackwood MP and Prime Minister David Cameron.[27]
- 2020 onwards: a vaccine against COVID-19, the Oxford–AstraZeneca COVID-19 vaccine, has been created and approved, and as of 2021 is in worldwide use along several other vaccines such as the Pfizer–BioNTech COVID-19 vaccine.[28][29]
Funding
The OVG is funded not only by its alma mater and UK government bodies such as the
The group has earned attention from international funders like the
The probable commercial success of the
Vaccine Knowledge Project
In 2011, the group launched the Vaccine Knowledge Project, funded by the Oxford Biomedical Research Centre.[33] The project website aims to provide independent, evidence-based information about vaccines and infectious diseases. The NHS Choices website lists the Vaccine Knowledge website as a recommended external link on several of its pages.[34][35][36] The website has also been referenced in the national media in the UK, particularly during the 2014-15 US measles outbreak originating in Disneyland California.[37][38] The project is a member of the Vaccine Safety Net.[39]
Awards
In November 2021 the team were awarded a Pride of Britain Award for their work on the COVID-19 vaccine.[40]
References
- ^ Oxford Vaccine Group website. Retrieved 25 June 2015
- ^ Biography of Richard Moxon, The Jenner Institute website, University of Oxford. Retrieved 25 June 2015
- ^ a b Sarah Boseley, Health Editor (15 May 2008). "Meningitis B tests raise hope of vaccine". The Guardian. Retrieved 25 June 2015.
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has generic name (help) - ^ Denis Campbell (16 November 2012). "Doctors hail meningitis vaccine 'breakthrough'". The Guardian. Retrieved 25 June 2015.
- ^ "Primary Care and Vaccines Collaborative Clinical Trials Unit website. Retrieved 25 June 2015". Archived from the original on 27 November 2015. Retrieved 4 August 2015.
- ^ List of registered clinical trials units on the UK Clinical Research Collaboration website. Retrieved 25 June 2015
- ^ List of UKPVG participating organisations on the UK Paediatric Vaccine Group website. Retrieved 25 June 2015
- ^ Paediatric Infectious Disease and Immunology website. Retrieved 25 June 2015
- ^ Oxford Vaccine Group signature on the All Trials Campaign website. Retrieved 25 June 2015
- ^ Joint Committee on Vaccination and Immunisation membership. Retrieved 25 June 2015
- ^ Science Media Centre, 15 March 2015. Retrieved 25 June 2015
- ^ Science Media Centre, 16 November 2012. Retrieved 25 June 2015
- ^ "Meningitis C vaccine 'wears off in early teens'". BBC News. 7 May 2010. Retrieved 25 June 2015.
- ^ Perrett KP, et al. Antibody persistence after serogroup C meningococcal conjugate immunization of United Kingdom primary-school children in 1999-2000 and response to a booster: a phase 4 clinical trial. Clinical Infectious Diseases 2010 Jun 15;50(12):1601-10
- ^ "Teen jab theory over meningitis C". BBC News. 6 June 2008. Retrieved 25 June 2015.
- ^ "Meningitis C vaccine 'wears off in early teens'". BBC News. 7 May 2010. Retrieved 25 June 2015.
- ^ Fergus Walsh (24 May 2006). "I am testing new bird flu jab". BBC News. Retrieved 25 June 2015.
- ^ Leroux-Roels I, et al. Humoral and cellular immune responses to split-virion H5N1 influenza vaccine in young and elderly adults. Vaccine 2009 Nov 16;27(49):6918-25.
- ^ Fergus Walsh (20 October 2006). "Meningitis B vaccine trials begin". BBC News. Retrieved 25 June 2015.
- ^ "Child swine flu vaccine trial results published". BBC News. 28 May 2010. Retrieved 25 June 2015.
- ^ "Children respond well to swine flu vaccines, trial shows". The Guardian. 28 May 2010. Retrieved 25 June 2015.
- BMJ2010;340:c2649
- ^ Reg Little (18 February 2010). "Never-ending war on disease". The Oxford Times. Retrieved 25 June 2015.
- ^ EUCLIDS work packages. Retrieved 25 June 2015
- ^ Fergus Walsh (6 January 2015). "Ebola: New vaccine trial begins". BBC News. Retrieved 25 June 2015.
- ^ "Oxford University doctors and scientists start trials for new Ebola vaccine". ITV News. 6 January 2015. Retrieved 25 June 2015.
- ^ Transcript of Oral Answers to Questions – Prime Minister – in the House of Commons at 11:30 am on 14 January 2015. Retrieved 25 June 2015
- ^ Gallagher, James (20 July 2020). "Coronavirus: Oxford vaccine triggers immune response". BBC. Retrieved 21 July 2020.
- ^ "Oxford University breakthrough on global COVID-19 vaccine". Oxford University. 23 November 2020.
- ^ "Funding for new COVID-19 studies awarded to OVG's project on infectious disease immunity in children". University of Oxford, Department of Paediatrics, Level 2, Children's Hospital, John Radcliffe, Headington, Oxford, OX3 9DU. 17 April 2020.
- ^ a b "Oxford Vaccine Group". University of Oxford Medical Sciences Division. April 2014.
- ^ Hancock, Jay (25 August 2020). "They Pledged to Donate Rights to Their COVID Vaccine, Then Sold Them to Pharma". KAISER FAMILY FOUNDATION. Kaiser Health News.
- ^ Vaccine Knowledge homepage. Retrieved 25 June 2015
- ^ NHS Choices page on the MenC vaccine with external link to Vaccine Knowledge website. Retrieved 25 June 2015
- ^ NHS Choices page on the 3-in-1 teenage booster vaccine with external link to Vaccine Knowledge website. Retrieved 25 June 2015
- ^ NHS Choices page on Vaccine Myths with external link to Vaccine Knowledge website. Retrieved 25 June 2015
- ^ Claire Armitstead (2 February 2015). "Roald Dahl becomes sage of US measles outbreak". The Guardian. Retrieved 25 June 2015.
- ^ Jules Montague (10 February 2015). "We should listen to Roald Dahl, not Jenny McCarthy, on vaccinating our children". The Guardian. Retrieved 25 June 2015.
- ^ "Vaccine Safety Net: members". Vaccine Safety Net. Retrieved 3 January 2021.
- ^ "Pride of Britain Awards". Retrieved 4 November 2021.