Oxycodone/paracetamol

Source: Wikipedia, the free encyclopedia.
"Percocet" and "Percs" redirect here. For the band, see
Percocettes. For the supercomputer technology, see PERCS. For the cleaning chemical PERC, see tetrachloroethylene
.

Oxycodone/paracetamol
Combination of
Anilide analgesic
Clinical data
Trade namesPercocet, others
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
KEGG
CompTox Dashboard (EPA)
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Oxycodone/paracetamol, sold under the brand name Percocet among others, is a

fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.[1]

In 2021, it was the 75th most commonly prescribed medication in the United States, with more than 8 million prescriptions.[2][3]

History

The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106.[4]

Society and culture

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet,

acetaminophen overdose and associated liver damage.[6]

In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.[7][8][9]

In March 2017, US President Donald Trump initiated the Opioid and Drug Abuse Commission.[10] In July 2017, a draft report was published.[11]

References

  1. ^ a b "Percocet- oxycodone hydrochloride and acetaminophen tablet". DailyMed. Retrieved 17 October 2021.
  2. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  3. ^ "Acetaminophen; Oxycodone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  4. ^ "Percocet: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 17 October 2021.
  5. ^ "FDA May Restrict Acetaminophen". WebMD.
  6. ^ Harris G (30 June 2009). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. Retrieved 22 May 2010.
  7. PMID 19969578
    .
  8. PMID 19969577
    .
  9. ^ "Deaths from opioid use have doubled; five-fold increase in oxycodone deaths". Canadian Medical Association Journal. 7 December 2009. Retrieved 31 May 2012.
  10. ^ "Presidential Executive Order Establishing the President's Commission on Combating Drug Addiction and the Opioid Crisis". 29 March 2017. Archived from the original on 30 March 2017.
  11. The White House
    .
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