Oxygen rebound mechanism

In

C-H activation.^[1]^[2]

Steps in an oxygen rebound mechanism: H-atom abstraction, oxygen rebound, alcohol decomplexation. The formal charge on the porphyrin changes from 1- to the more usual 2-.

Three main classes of these enzymes are cytochrome P450, alpha-ketoglutarate-dependent hydroxylases, and nonheme-diiron hydroxylases.

References

PMID 27909920
.

^ Oxygenation reactions by high-valent iron-oxo species are "C–H activation" reactions in the broad sense of the term. Some authors would call this a C–H functionalization but not an "activation" (in its narrow sense), since a metal–carbon bond is not involved in the C–H bond cleaving process.

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[1] PMID 27909920
.

[2] Oxygenation reactions by high-valent iron-oxo species are "C–H activation" reactions in the broad sense of the term. Some authors would call this a C–H functionalization but not an "activation" (in its narrow sense), since a metal–carbon bond is not involved in the C–H bond cleaving process.

[1]

[2]