PBX2

Source: Wikipedia, the free encyclopedia.
PBX2
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_002586

NM_017463

RefSeq (protein)

NP_002577

NP_059491

Location (UCSC)Chr 6: 32.18 – 32.19 MbChr 17: 34.81 – 34.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[5][6]

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[6]

Interactions

PBX2 has been shown to

interact with HOXA9.[7]

References

  1. ^ a b c ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 GRCh38: Ensembl release 89: ENSG00000224952, ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034673 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 7835890
    .
  6. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
  7. PMID 10082572
    .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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