PHA-543,613

PHA-543,613

Identifiers
IUPAC name N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide
JSmol)	Interactive image
SMILES C1CN2CCC1[C@H](C2)NC(=O)C3=NC=C4C(=C3)C=CO4
InChI InChI=1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1 Key:IPKZCLGGYKRDES-ZDUSSCGKSA-N
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PHA-543,613 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.^[1] It reduces excitotoxicity^[2] and protects striatal dopaminergic neurons in rat models.^[3] It also potentiates cognitive enhancement from memantine,^[4][5] decreases dynorphin release^[6] and inhibits GSK-B3.^[7]

See also

• Nefiracetam

References