Phosphatidylinositol (3,4,5)-trisphosphate
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| Names | |
|---|---|
| Other names
PI(3,4,5)P3, PtdIns(3,4,5)P3
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| Identifiers | |
| ChEBI | |
| KEGG | |
| Properties | |
| C47H86O22P4 | |
| Molar mass | 1126.46 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I
Discovery
In 1988,
Function
PIP3 functions to activate downstream signaling components, the most notable one being the protein kinase Akt, which activates downstream anabolic signaling pathways required for cell growth and survival.[4]
PtdIns(3,4,5)P3 is dephosphorylated by the
The
Roles in the nervous system
PIP3 plays a critical role outside the cytosol, notably at the postsynaptic terminal of hippocampal cells. Here, PIP3 has been implicated in regulating synaptic strengthening and AMPA expression, contributing to long-term potentiation. Moreover, PIP3 suppression disrupts normal AMPA expression on the neuron membrane and instead leads to the accumulation of AMPA on dendritic spines, commonly associated with synaptic depression.[9]
PIP3 interacts with proteins to mediate synaptic plasticity. Of these proteins, Phldb2 has been shown to interact with PIP3 to induce and maintain long-term potentiation. In the absence of such an interaction, memory consolidation is impaired.[10]