PNU-120,596

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PNU-120,596
Identifiers
  • 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
JSmol)
  • COc1cc(OC)c(Cl)cc1NC(=O)Nc2noc(C)c2
  • InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18) ☒N
  • Key:CEIIEALEIHQDBX-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

PNU-120596 is a drug that acts as a potent and selective

positive allosteric modulator for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] It is used in scientific research into cholinergic regulation of dopamine and glutamate release in the brain.[3][4][5]

References

  1. PMID 15858066
    .
  2. PMID 18791069
    .
  3. S2CID 13289370
    .
  4. PMID 19411608
    .
  5. S2CID 29929913
    .
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