PNU-282,987

PNU-282,987

Identifiers
IUPAC name N-[(3'R)-1'-azabicyclo[2.2.2]oct-3'-yl]-4-chlorobenzamide
JSmol)	Interactive image
SMILES C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl
InChI InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1 Key:WECKJONDRAUFDD-ZDUSSCGKSA-N
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PNU-282,987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.^[1][2] In animal studies, it shows nootropic effects, and derivatives may be useful in the treatment of schizophrenia,^[3][4] although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget.^[5] PNU-282987 has been shown to initiate signaling that leads to adult neurogeneis in mammals.^[6]

References