PROP1

Source: Wikipedia, the free encyclopedia.
PROP1
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_006261

NM_008936

RefSeq (protein)

NP_006252

NP_032962

Location (UCSC)Chr 5: 177.99 – 178 MbChr 11: 50.84 – 50.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein prophet of

PIT-1 is a protein that in humans is encoded by the PROP1 gene.[5][6]

PROP1 has both DNA-binding and transcriptional activation ability. Its expression leads to ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes, and caudomedial thyrotropes. Inactivating mutations in PROP1 result in deficiencies of luteinizing hormone (LH; MIM 152780), follicle-stimulating hormone (FSH; MIM 136530), growth hormone (GH; MIM 139250), prolactin (PRL; MIM 176760), and thyroid-stimulating hormone (TSH; MIM 188540). See combined pituitary hormone deficiency (CPHD; MIM 262600).[supplied by OMIM][6]

References

  1. ^ a b c ENSG00000175325, ENSG00000274382 GRCh38: Ensembl release 89: ENSG00000280635, ENSG00000175325, ENSG00000274382 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044542 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. S2CID 6882625
    .
  6. ^ a b "Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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