PRRX1
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| Location (UCSC) | Chr 1: 170.66 – 170.74 Mb | Chr 1: 163.07 – 163.14 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.[5][6]
Function
The DNA-associated protein encoded by this gene is a member of the paired family of
mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.[6]
Role in mesenchymal stem cell differentiation
Prrx1 expression is restricted to the
tumor necrosis factor-alpha to inhibit osteoblast differentiation.[14]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116132 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026586 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 1206059.
- ^ a b "Entrez Gene: PRRX1 paired related homeobox 1".
- PMID 1383943.
- PMID 8101172.
- ^ PMID 9876178.
- PMID 9817598.
- PMID 1360403.
- PMID 9729491.
- PMID 23250756.
- PMID 20683885.
Further reading
- Grueneberg DA, Simon KJ, Brennan K, Gilman M (1995). "Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins". Mol. Cell. Biol. 15 (6): 3318–26. PMID 7760827.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (October 1997). "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. 11 (19): 2482–93. PMID 9334314.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Nakamura T, Yamazaki Y, Hatano Y, Miura I (1999). "NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)". Blood. 94 (2): 741–7. PMID 10397741.
- Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M (2001). "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities". J. Biol. Chem. 276 (1): 819–26. PMID 11036080.
- Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (November 2000). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm. Genome. 11 (11): 1000–5. S2CID 9937434.
- Jones FS, Meech R, Edelman DB, Oakey RJ, Jones PL (July 2001). "Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease". Circ. Res. 89 (2): 131–8. PMID 11463719.
- Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. S2CID 26145639.
- Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. PMID 16582099.
- Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. PMID 16710414.
- Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM (January 2007). "Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology". Cancer Res. 67 (2): 546–54. PMID 17234762.
External links
- PRRX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.