PZM21

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PZM21
Identifiers
  • 1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
JSmol)
  • O=C(N[C@H](CC1=CSC=C1)C)NC[C@H](CC2=CC=C(O)C=C2)N(C)C
  • InChI=1S/C19H27N3O2S/c1-14(10-16-8-9-25-13-16)21-19(24)20-12-17(22(2)3)11-15-4-6-18(23)7-5-15/h4-9,13-14,17,23H,10-12H2,1-3H3,(H2,20,21,24)/t14-,17-/m0/s1
  • Key:MEDBIJOVZJEMBI-YOEHRIQHSA-N

PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain.[1] It is claimed to be a

respiratory depression, even at high doses.[4] This research was described as a compelling example of how modern high-throughput screening techniques can be used to discover new chemotypes with specific activity profiles, even at targets such as the μ-opioid receptor which have already been thoroughly investigated.[5] More recent research has suggested however that at higher doses, PZM21 is capable of producing classic opioid side effects such as respiratory depression and development of tolerance and may have only limited functional selectivity.[6]

See also

References

  1. PMID 27662248
    .
  2. PMID 27533032
    .
  3. S2CID 214771721
    .
  4. PMID 27533032
    .
  5. PMID 27533037
    .
  6. PMID 29582414
    .


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