Pacinian corpuscle
Pacinian corpuscle | |
---|---|
Details | |
Location | Skin |
Identifiers | |
Latin | corpusculum Pacinian |
MeSH | D010141 |
TH | H3.11.06.0.00009 |
FMA | 83604 |
Anatomical terms of microanatomy |
The Pacinian corpuscle, lamellar corpuscle or Vater-Pacini corpuscle
Structure
Pacinian corpuscles are larger and fewer in number than Meissner's corpuscle, Merkel cells and Ruffini's corpuscles.[4]
The Pacinian corpuscle is approximately oval-cylindrical-shaped and 1 mm in length. The entire corpuscle is wrapped by a layer of connective tissue. Its capsule consists of 20 to 60 concentric lamellae (hence the alternative lamellar corpuscle) including fibroblasts and fibrous connective tissue (mainly Type IV and Type II collagen network), separated by gelatinous material, more than 92% of which is water.[5] It presents a whorled pattern on micrographs.
Function
Pacinian corpuscles are
These corpuscles are especially sensitive to vibrations, which they can sense even centimeters away.[4] Their optimal sensitivity is 250 Hz, and this is the frequency range generated upon fingertips by textures made of features smaller than 1 µm.[7][8] Pacinian corpuscles respond when the skin is rapidly indented but not when the pressure is steady, due to the layers of connective tissue that cover the nerve ending.[4] It is thought that they respond to high-velocity changes in joint position. They have also been implicated in detecting the location of touch sensations on handheld tools.[9]
Pacinian corpuscles have a large receptive field on the skin's surface with an especially sensitive center.[4]
Mechanism
Pacinian corpuscles sense stimuli due to the deformation of their lamellae, which press on the membrane of the sensory neuron and causes it to bend or stretch.[10] When the lamellae are deformed, due to either application or release of pressure, a generator or receptor potential is created as it physically deforms the plasma membrane of the receptive area of the neuron, making it "leak" different cations through Mechanosensitive channels which initiates the receptor potential. This mechanotransduction process is also supported by distributed voltage sensitive ion channels in the inner-core and neurite of the corpuscles.[3] Due to generation of receptor potential in the receptive area of the neurite (especially near the heminode or half-node of the axon) the potential at the first Ranvier's node can reach certain threshold, triggering nerve impulses or action potentials at the first node of Ranvier. The first Ranvier's node of the myelinated section of the neurite is often found inside the capsule.[citation needed] This impulse is then transferred along the axon from node to node with the use of sodium channels and sodium/potassium pumps in the axon membrane.
Once the receptive area of the neurite is depolarized, it will depolarize the first node of Ranvier; however, as it is a rapidly adapting fibre, this does not carry on indefinitely, and the signal propagation ceases. This is a graded response, meaning that the greater the deformation, the greater the generator potential. This information is encoded in the frequency of impulses, since a bigger or faster deformation induces a higher impulse frequency. Action potentials are formed when the skin is rapidly distorted but not when pressure is continuous because of the mechanical filtering of the stimulus in the lamellar structure. The frequencies of the impulses decrease quickly and soon stop due to the relaxation of the inner layers of connective tissue that cover the nerve ending.
Discovery
Pacinian corpuscles were the first cellular sensory receptor ever observed. They were first reported by German anatomist and botanist
Additional images
-
Diagrammatic sectional view of the skin (magnified)
-
Schema (German)
-
Light micrograph showing three corpuscles in the center of the field
-
Micrograph of a Pacinian corpuscle
See also
- Pallesthesia
- List of human anatomical parts named after people
- Pacinian neuroma– a very rare benign tumor of Pacinian corpuscles
- Rayleigh wave#Possible detection by animals
References
- PMID 33156397.
- S2CID 24658742.
- ^ S2CID 15326972.
- ^ ISBN 0-8385-7701-6.
- S2CID 26734354.
- ^ Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark (2001). "Cutaneous and Subcutaneous Somatic Sensory Receptors". Neuroscience. 2nd edition. Sinauer Associates. Retrieved 31 July 2023.
- S2CID 14459552.
- .
- ^ Sima, Richard (23 December 2019). "The Brain Senses Touch beyond the Body". Scientific American. Retrieved 17 February 2020.
- ISBN 9780716799221.
- ^ S2CID 6094598.
- PMID 13513492.