para-Methoxy-N-methylamphetamine
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para-Methoxy-N-methylamphetamine (also known as PMMA, Red Mitsubishi), chemically known as methyl-MA, 4-methoxy-N-methylamphetamine, and 4-MMA (or 4-PMDA, as listed to its original physical name) is a
Its effects in humans are reputedly similar to those of PMA, but slightly more
The synthesis and effects of PMMA were described by American experimental chemist
Recreational use
PMMA has been found in tablets and capsules of the MDMA sold as "ecstasy". A number of deaths have been attributed to tablets sold as ecstasy that contained other substances, such as PMMA's structural analog, PMA.[7][8] Death can occur when an ecstasy user believes they are consuming recreational doses of MDMA, when they are in fact consuming a lethal dose of another substance with similar effects. PMA is of particular concern because it not only causes a release of serotonin but also acts as a monoamine oxidase inhibitor (MAOI); if it is used in combination with MDMA or another MDMA-like substance, serotonin syndrome can result.[9]
PMMA can be detected with reagent testing kits.
Deaths
In January 2011, the
In 2011, four deaths were recorded in Scotland as a result of ecstasy tablets which also contained PMMA.[11]
In January 2012, a number of ecstasy-related deaths in Canada in the previous year were linked to PMMA overdoses. In the single year, approximately 45 exposures occurred, resulting in 21 deaths. Cases were centred primarily in Calgary and Vancouver.[12][13][14][15][16][17]
In September 2012, the deaths of two men in County Cork, Ireland, have been linked to PMMA overdoses.[18] In the same month, the death of a man in Queensland, Australia was attributed to PMMA.[19]
In June 2013 a PMMA-related death occurred in the Dutch city of 's-Hertogenbosch.[20] Two months later, In August 2013, another possibly PMMA-related death occurred in the nearby town of Sliedrecht.[21][22][23]
In January 2015 in the UK four people died, suspected of taking ecstasy containing PMMA.[24] In the same month, in Sweden, another man died from ecstasy laced with PMMA.[25]
In May 2015 a young woman died in Dublin, Ireland, after taking what is suspected to be PMMA.[26]
In April 2016 four young Argentines and one Uruguayan died during a massive rave called "Time Warp" in Buenos Aires and five more were hospitalized. PMMA was found in their bodies. [27]
Legal status
United States
On June 25, 2021 the DEA finalized a rule placing PMMA on the Controlled Substance Act federal Schedule as a Schedule I substance effective July 26, 2021.[28]
United Kingdom
PMMA is controlled as a Schedule 1,
See also
- para-Methoxyamphetamine (PMA)
- 2-Methoxymethamphetamine (Methoxyphenamine)
- 3-Methoxymethamphetamine (MMMA)
- 4-Fluoromethamphetamine (4-FMA)
- 4-Methylmethamphetamine(4-MMA)
- 4-Methoxymethcathinone(bk-PMMA)
- Venlafaxine
References
- ^ Anvisa (24 July 2023). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 25 July 2023). Archived from the original on 27 August 2023. Retrieved 27 August 2023.
- PMID 12935573.
- ^ "Five B.C. deaths linked to lethal chemical PMMA". Vancouver Sun. 13 January 2012.
- S2CID 28758326.
- S2CID 41953749.
- S2CID 42519181.
- S2CID 28006785.
- S2CID 11987961.
- S2CID 42213032.
- ^ "PMMA deaths in Holland". nu.nl. Retrieved 8 June 2011.
- ^ "Warning over ecstasy pills that raise overdose risk". BBC News. 16 December 2011. Archived from the original on 25 April 2012.
- ^ "Rare chemical found in fatal ecstasy". The Province. 15 January 2012. Archived from the original on 17 January 2012. Retrieved 12 January 2012.
- ^ "Overdose death investigated". Nanton News. 24 January 2012.
- ^ "Seized substances sent for testing after suspected overdose". Calgary Herald. Archived from the original on 27 January 2012. Retrieved 24 January 2012.
- ^ "Tainted ecstasy linked to five Calgary deaths could be from B.C." Vancouver Sun. 12 January 2012. Archived from the original on 4 March 2013. Retrieved 12 January 2012.
- ^ "Authorities renew warning about street drugs". The City of Calgary Newsroom. Archived from the original on 15 January 2012. Retrieved 11 January 2012.
- ^ "Ecstasy laced with meth in overdose cases". Archived from the original on 12 January 2012. Retrieved 12 January 2012.
- ^ "Dangerous drug linked to Kinsale deaths". Irish Independent. 13 September 2012. Archived from the original on 13 September 2012. Retrieved 13 September 2012.
- ^ "Queensland Police investigate three deaths linked to 'poison pill' ecstasy overdoses". news.com.au. 9 September 2012. Retrieved 30 September 2012.
- ^ "Den Bosch issues a warning for dangerous XTC-pills". nu.nl. Retrieved 12 June 2013.
- ^ "Tiener overleden aan drugs". Archived from the original on 29 August 2013. Retrieved 30 August 2013.
- ^ "Naomi (16): dood door roze xtc-pil". 26 August 2013. Archived from the original on 29 August 2013. Retrieved 26 August 2013.
- ^ "Waarschuwing: dodelijke 'XTC' in omloop". Archived from the original on 29 August 2013. Retrieved 26 August 2013.
- ^ "Man charged after ecstasy deaths". BBC News. 15 May 2018. Archived from the original on 13 May 2018.
- ^ "Varning för livsfarlig ecstasy" (in Swedish). 2 January 2015. Archived from the original on 5 January 2015. Retrieved 4 January 2015.
- ^ "Dublin student dies after taking PMMA tablets in nightclub". irishexaminer.com. 17 May 2015. Archived from the original on 18 May 2015.
- ^ Himitian, Evangelina (17 April 2016). "Conmoción por la muerte de cinco jóvenes en una fiesta electrónica". La Nación (in Spanish). Archived from the original on 19 April 2016.
- ^ "Schedules of Controlled Substances: Placement of para-Methoxymethamphetamine (PMMA) in Schedule I". federalregister.gov. 25 June 2021.