Paritaprevir
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Trade names | Viekira Pak (in combination with ombitasvir, ritonavir and dasabuvir), Technivie/Viekirax (in combination with ombitasvir and ritonavir) |
Other names | Veruprevir; ABT-450 |
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Routes of administration | Oral |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | was not evaluated |
Protein binding | 97–98.6% |
Metabolism | Hepatic, CYP3A4 and CYP3A5 |
Onset of action | 4 to 5 hours |
Elimination half-life | 5.5 hours |
Excretion | feces (88%), urine (8,8%) |
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Paritaprevir (previously known as ABT-450) is an acylsulfonamide4A serine protease[2] manufactured by Abbott Laboratories[3] that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1.[4] Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3.[5]: 248
Paritaprevir was a component of
Viekira Pak and Technivie.[6] In May 2018, the FDA announced that Technivie and Viekira were to be discontinued. The discontinuation was voluntary and not related to the safety, quality, or efficacy of the medicine. It was estimated that both medications would be available until January 1, 2019.[7]
References
- ISBN 9781904455783. Retrieved 28 April 2014.
- ISBN 9780199844296. Retrieved 28 April 2014.
- ^ "Abbott Announces Phase 3 Hepatitis C Program Details". Abbott company website. Abbott Laboratories. Retrieved 28 April 2014.
- PMID 24428468.
- ISBN 978-3-924774-90-5. Archived from the original(PDF) on 29 April 2014. Retrieved 28 April 2014.
- ^ "TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information" (PDF). AbbVie Inc., North Chicago, IL 60064. Archived from the original (PDF) on 7 August 2015. Retrieved 28 July 2015.
- ^ "Current and Resolved Drug Shortages and Discontinuations Reported to FDA".