Pehr Victor Edman
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Pehr Edman
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Pehr Victor Edman | |
|---|---|
Max-Planck-Institut of Biochemistry | |
| Doctoral advisor | Eric Jorpes[citation needed] |
Pehr Victor Edman (14 April 1916 — 19 March 1977) was a Swedish biochemist. He developed a method for sequencing proteins; the Edman degradation.[1]
Early life
Edman was born in
Karolinska Institutet where he earned his doctoral degree under advice from Professor Erik Jorpes
in 1946.
Developing the Edman Degradation
At the time Edman started working on Angiotensin, it was just being recognized that proteins are distinct entities with a defined
University of Lund, he published his first paper using the method later known as Edman degradation
, to determine the sequence of a protein. To his death, he continued to work to improve the method to be able to determine longer stretches with smaller amounts of sample.
Late career
In 1957, he moved to Australia to be the director of St. Vincent's School of Medical Research. In 1967, he successfully developed an automated protein sequencer, called the sequenator, with his assistant Geoffrey Begg.
In 1972, he moved to the
Max-Planck-Institut of Biochemistry, Martinsried near Munich. He worked with his second wife, Agnes Henschen, and she used Edman's method to sequence fibrinogen
.
In 1977, Edman died of a brain
tumor
after a short coma.
References
- ^ S2CID 42718142.
EDMAN P. A method for the determination of amino acid sequence in peptides. Arch Biochem. 1949 Jul;22(3):475. PMID 18134557.
