Peliosis hepatis
| Peliosis hepatis | |
|---|---|
 | |
| The CT scan of a patient with peliosis hepatis (left): The follow-up CT (right) after 7 years shows full remission. | |
| Specialty | Gastroenterology, hepatology |
| Symptoms | asymptomatic, abdominal pain, jaundice |
Peliosis hepatis is an uncommon
Peliosis hepatis is often erroneously written "peliosis hepatitis", despite its not being one of the
Signs and symptoms
Often, peliosis hepatis causes no symptoms (asymptomatic). In other cases, it may be identified after blood tests show abnormalities in liver enzymes.[6]
Less commonly, peliosis hepatis may cause abdominal pain, especially right upper quadrant pain, or jaundice.[6]
Presentation
Disease associations
- Infections: HIV, bacillary peliosis (caused by genus Bartonella, bacteria responsible for cat-scratch disease which are identified histologically adjacent to the peliotic lesions[7]), Staphylococcus aureus[8]
- Chronic conditions: End stage kidney failure, kwashiorkor, tuberculosis, and other chronic infections
- Malignancy: hepatocarcinoma[9]
- Kidney transplants: It can be found in up to 20% patients, can be related to azathioprine or cyclosporine use, and may be associated with increased risk of transplant rejection.[10][11]
- Drugs and toxins:
Pathophysiology
The
Peliosis hepatis is associated with infections, cancers, organ transplantation, blood disorders, autoimmune conditions, and certain medications.[6]
Two
Diagnosis
The condition is typically asymptomatic and is discovered following evaluation of abnormal
Other cystic conditions of liver
- Polycystic liver disease
- Solitary congenital cysts
- Congenital hepatic fibrosis
- Hydatid cyst
- Von Meyenburg complexes
- Caroli disease (type V choledochal cyst)
- Type IV choledochal cysts
Treatment
Treatment is usually directed towards management of the underlying cause. Withdrawal of azathioprine leads to remission in
Epidemiology
Peliosis hepatis usually affects adults, though may occur in children.[6] Peliosis hepatis occurs equally in men and women.[15][6]
History
Peliosis hepatis was first described in 1861.[15]
References
- ^ ISBN 978-1-4160-0245-1. Chapter 80
- S2CID 19074965.
- ^ "Henry George Liddell, Robert Scott, A Greek-English Lexicon". Retrieved 2007-06-11.
- ^ "Charlton T. Lewis, Charles Short, A Latin Dictionary". Retrieved 2007-07-02.
- ^ "Henry George Liddell, Robert Scott, A Greek-English Lexicon". Retrieved 2007-07-02.
- ^ )
- PMID 9407154.
- PMID 2233946.
- PMID 3278593.
- PMID 8201214.
- PMID 8053054.
- ISBN 978-0-7216-4563-6.
- PMID 10881786.
- PMID 14088761.
- ^ S2CID 19321062.